Rapamycin attenuates Th2-driven experimental allergic conjunctivitis.
Identifieur interne : 000511 ( Main/Exploration ); précédent : 000510; suivant : 000512Rapamycin attenuates Th2-driven experimental allergic conjunctivitis.
Auteurs : Soojung Shin [Corée du Sud] ; Ji Hyun Lee [Corée du Sud] ; Hyun Jung Lee [Corée du Sud] ; Sun Young Chang [Corée du Sud] ; So-Hyang Chung [Corée du Sud]Source :
- Clinical immunology (Orlando, Fla.) [ 1521-7035 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Conjonctive (effets des médicaments et des substances chimiques), Conjonctive (immunologie), Conjonctive (métabolisme), Conjonctivite allergique (génétique), Conjonctivite allergique (immunologie), Conjonctivite allergique (prévention et contrôle), Expression des gènes (effets des médicaments et des substances chimiques), Expression des gènes (immunologie), Femelle (MeSH), Immunoglobuline E (immunologie), Immunoglobuline E (sang), Immunoglobuline G (immunologie), Immunoglobuline G (sang), Immunosuppresseurs (pharmacologie), Lymphocytes auxiliaires Th2 (immunologie), Ovalbumine (immunologie), Sirolimus (pharmacologie), Souris de lignée BALB C (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Conjonctive, Expression des gènes.
- génétique : Conjonctivite allergique.
- immunologie : Conjonctive, Conjonctivite allergique, Expression des gènes, Immunoglobuline E, Immunoglobuline G, Lymphocytes auxiliaires Th2, Ovalbumine.
- métabolisme : Conjonctive.
- pharmacologie : Immunosuppresseurs, Sirolimus.
- prévention et contrôle : Conjonctivite allergique.
- sang : Immunoglobuline E, Immunoglobuline G.
- Animaux, Femelle, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Animals (MeSH), Conjunctiva (drug effects), Conjunctiva (immunology), Conjunctiva (metabolism), Conjunctivitis, Allergic (genetics), Conjunctivitis, Allergic (immunology), Conjunctivitis, Allergic (prevention & control), Female (MeSH), Gene Expression (drug effects), Gene Expression (immunology), Immunoglobulin E (blood), Immunoglobulin E (immunology), Immunoglobulin G (blood), Immunoglobulin G (immunology), Immunosuppressive Agents (pharmacology), Mice, Inbred BALB C (MeSH), Ovalbumin (immunology), Sirolimus (pharmacology), Th2 Cells (immunology).
- MESH :
- chemical , blood : Immunoglobulin E, Immunoglobulin G.
- drug effects : Conjunctiva, Gene Expression.
- genetics : Conjunctivitis, Allergic.
- immunology : Conjunctiva, Conjunctivitis, Allergic, Gene Expression, Immunoglobulin E, Immunoglobulin G, Ovalbumin, Th2 Cells.
- metabolism : Conjunctiva.
- chemical , pharmacology : Immunosuppressive Agents, Sirolimus.
- prevention & control : Conjunctivitis, Allergic.
- Animals, Female, Mice, Inbred BALB C.
Abstract
Allergic conjunctivitis is mediated by eosinophilic infiltration and Th2 type immune responses. This study aims to elucidate the role of rapamycin, mTOR inhibitor, on OVA-induced experimental allergic conjunctivitis (EAC). Rapamycin administration intraperitoneally markedly reduced clinical signs, total and OVA-specific IgE and IgG1/G2a ratio in serum, and conjunctival eosinophilic infiltration. Infiltrations of CD11c+ dendritic cells and CD4+ T cells, and the expressions of chemokines and adhesion molecules in the conjunctiva were attenuated in rapamycin-treated mice, as well as decreased Th1 and Th2 cytokines in the cervical lymph nodes compared to non-treated mice. The expression of mTOR signaling proteins was increased in EAC and reduced by rapamycin treatment. Topical application of rapamycin was also proved to show reduced clinical signs, eosinophil infiltration, and Th2 type immune responses comparable to those from intraperitoneal injection of rapamycin. These findings suggest the therapeutic implications of rapamycin in the attenuation of allergic conjunctivitis.
DOI: 10.1016/j.clim.2018.02.004
PubMed: 29432811
Affiliations:
Links toward previous steps (curation, corpus...)
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Catholic Institute for Visual Science, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Catholic Institute for Visual Science, The Catholic University of Korea, College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Ji Hyun" sort="Lee, Ji Hyun" uniqKey="Lee J" first="Ji Hyun" last="Lee">Ji Hyun Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Catholic Institute for Visual Science, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Catholic Institute for Visual Science, The Catholic University of Korea, College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Hyun Jung" sort="Lee, Hyun Jung" uniqKey="Lee H" first="Hyun Jung" last="Lee">Hyun Jung Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Catholic Institute for Visual Science, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Catholic Institute for Visual Science, The Catholic University of Korea, College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Chang, Sun Young" sort="Chang, Sun Young" uniqKey="Chang S" first="Sun Young" last="Chang">Sun Young Chang</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Microbiology, College of Pharmacy, Ajou University, Suwon, Kyeonggi-do, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Microbiology, College of Pharmacy, Ajou University, Suwon, Kyeonggi-do</wicri:regionArea><wicri:noRegion>Kyeonggi-do</wicri:noRegion></affiliation></author><author><name sortKey="Chung, So Hyang" sort="Chung, So Hyang" uniqKey="Chung S" first="So-Hyang" last="Chung">So-Hyang Chung</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Catholic Institute for Visual Science, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea. 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This study aims to elucidate the role of rapamycin, mTOR inhibitor, on OVA-induced experimental allergic conjunctivitis (EAC). Rapamycin administration intraperitoneally markedly reduced clinical signs, total and OVA-specific IgE and IgG1/G2a ratio in serum, and conjunctival eosinophilic infiltration. Infiltrations of CD11c<sup>+</sup> dendritic cells and CD4<sup>+</sup> T cells, and the expressions of chemokines and adhesion molecules in the conjunctiva were attenuated in rapamycin-treated mice, as well as decreased Th1 and Th2 cytokines in the cervical lymph nodes compared to non-treated mice. The expression of mTOR signaling proteins was increased in EAC and reduced by rapamycin treatment. Topical application of rapamycin was also proved to show reduced clinical signs, eosinophil infiltration, and Th2 type immune responses comparable to those from intraperitoneal injection of rapamycin. These findings suggest the therapeutic implications of rapamycin in the attenuation of allergic conjunctivitis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29432811</PMID><DateCompleted><Year>2019</Year><Month>07</Month><Day>01</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1521-7035</ISSN><JournalIssue CitedMedium="Internet"><Volume>190</Volume><PubDate><Year>2018</Year><Month>05</Month></PubDate></JournalIssue><Title>Clinical immunology (Orlando, Fla.)</Title><ISOAbbreviation>Clin Immunol</ISOAbbreviation></Journal><ArticleTitle>Rapamycin attenuates Th2-driven experimental allergic conjunctivitis.</ArticleTitle><Pagination><MedlinePgn>1-10</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1521-6616(17)30655-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.clim.2018.02.004</ELocationID><Abstract><AbstractText>Allergic conjunctivitis is mediated by eosinophilic infiltration and Th2 type immune responses. This study aims to elucidate the role of rapamycin, mTOR inhibitor, on OVA-induced experimental allergic conjunctivitis (EAC). Rapamycin administration intraperitoneally markedly reduced clinical signs, total and OVA-specific IgE and IgG1/G2a ratio in serum, and conjunctival eosinophilic infiltration. Infiltrations of CD11c<sup>+</sup> dendritic cells and CD4<sup>+</sup> T cells, and the expressions of chemokines and adhesion molecules in the conjunctiva were attenuated in rapamycin-treated mice, as well as decreased Th1 and Th2 cytokines in the cervical lymph nodes compared to non-treated mice. The expression of mTOR signaling proteins was increased in EAC and reduced by rapamycin treatment. Topical application of rapamycin was also proved to show reduced clinical signs, eosinophil infiltration, and Th2 type immune responses comparable to those from intraperitoneal injection of rapamycin. These findings suggest the therapeutic implications of rapamycin in the attenuation of allergic conjunctivitis.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shin</LastName><ForeName>Soojung</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Catholic Institute for Visual Science, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Ji Hyun</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Catholic Institute for Visual Science, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Hyun Jung</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Catholic Institute for Visual Science, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Sun Young</ForeName><Initials>SY</Initials><AffiliationInfo><Affiliation>Laboratory of Microbiology, College of Pharmacy, Ajou University, Suwon, Kyeonggi-do, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>So-Hyang</ForeName><Initials>SH</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Catholic Institute for Visual Science, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea. Electronic address: chungsh@catholic.ac.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>02</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Immunol</MedlineTA><NlmUniqueID>100883537</NlmUniqueID><ISSNLinking>1521-6616</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>37341-29-0</RegistryNumber><NameOfSubstance UI="D007073">Immunoglobulin E</NameOfSubstance></Chemical><Chemical><RegistryNumber>9006-59-1</RegistryNumber><NameOfSubstance UI="D010047">Ovalbumin</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003228" MajorTopicYN="N">Conjunctiva</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003233" MajorTopicYN="N">Conjunctivitis, Allergic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015870" MajorTopicYN="N">Gene Expression</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007073" MajorTopicYN="N">Immunoglobulin E</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010047" MajorTopicYN="N">Ovalbumin</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018418" MajorTopicYN="N">Th2 Cells</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Allergic conjunctivitis</Keyword><Keyword MajorTopicYN="Y">Dendritic cells</Keyword><Keyword MajorTopicYN="Y">Eosinophil</Keyword><Keyword MajorTopicYN="Y">Rapamycin</Keyword><Keyword MajorTopicYN="Y">Th2 type immune response</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>09</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>01</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>02</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>7</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29432811</ArticleId><ArticleId IdType="pii">S1521-6616(17)30655-1</ArticleId><ArticleId IdType="doi">10.1016/j.clim.2018.02.004</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Shin, Soojung" sort="Shin, Soojung" uniqKey="Shin S" first="Soojung" last="Shin">Soojung Shin</name></region><name sortKey="Chang, Sun Young" sort="Chang, Sun Young" uniqKey="Chang S" first="Sun Young" last="Chang">Sun Young Chang</name><name sortKey="Chung, So Hyang" sort="Chung, So Hyang" uniqKey="Chung S" first="So-Hyang" last="Chung">So-Hyang Chung</name><name sortKey="Lee, Hyun Jung" sort="Lee, Hyun Jung" uniqKey="Lee H" first="Hyun Jung" last="Lee">Hyun Jung Lee</name><name sortKey="Lee, Ji Hyun" sort="Lee, Ji Hyun" uniqKey="Lee J" first="Ji Hyun" last="Lee">Ji Hyun Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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